By H. Huland (auth.), Professor W. B. Peeling, Professor Dr. med. Hermann Becker (eds.)

The growth made within the prognosis of prostate carcinoma with the creation of transrectal ultrasound (TRUS), PSA selection, and ultrasound-guided prostate biopsy in addition to enhanced working strategies have resulted in a substantial bring up within the variety of radical prostate operations being played and therefore elevated the probabilities of good fortune of healing therapy in lots of sufferers. using neoadjuvant endocrine remedy prior to radical prostatectomy remains to be an issue of discussion. it is going to definitely basically be attainable to make a last judgement at the foundation of long term observations. This e-book takes into consideration that simply a global alternate of recent findings can create the mandatory stipulations for more suitable treatment.

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Verh Detsch Ges Urol 32: 9-16 Fair WR, Aprikian A, Sogani P, Reuter V; Whitmore WF (1993) The role of neoadjuvant hormonal manipulation in localized prostatic cancer. Cancer 71: 1031-1038 Flamm J, Fischer M, Holt! W, Pfluger H, Tomschi W (1991) Complete androgen deprivation prior to radical prostatectomy in patients with stage T3 cancer of the prostate. Eur Urol: XX 192-195 Neoadjuvant Androgen Deprivation 45 Kennedy TJ, Sonneland AM, Marlett MM, Troup RH (1992) Luteinizing hormone-releasing hormone downstaging of clinical stage C prostate cancer.

J Urol 132: 690-692 Thompson 1M, Rounder JB, Teague JL, Peek M, Spence CR (1987) Impact of routine screening for adenocarcinoma of the prostate on stage distribution. J Urol 137: 424-426 Waterhouse RL, Resnick MI (1989) The use of transrectal prostatic ultrasonography in the evaluation of patients with prostatic carcinoma. J Urol 141: 233-239 Carcinoma of the Prostate: Science and Treatment J. WAXMAN Carcinoma of the prostate is the second most common cause of cancer in men and its incidence has virtually doubled over the last 30 years.

7 %). In addition to the down-sizing effect, CAD results in an androgen-free or androgen-neutralising environment at operation, as was particularly pointed out by the group of Monfette and Labrie (1989, 1991). This group believes that CAD prevents the implantation of intraoperatively mobilised tumour cells. Only long-term results from prospective randomised studies will allow testing of this possible positive effect of CAD, however. Prospective randomised phase III studies are under way (Table 2) in which the early and long-term effects of neoadjuvant medical androgen deprivation will be tested.

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