By H. Luellmann, D. Bieger

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Extra resources for Color Atlas of Pharmacology (Thieme Flexibook)

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Although the cells are tightly connected by continuous junctions, they possess pores (arrows in EM micrograph, bottom right) that are closed only by diaphragms. , proteins such as insulin (G: insulin storage granules. Penetrability of macromolecules is determined by molecular size and electrical charge. Fenestrated endothelia are found in the capillaries of the gut and endocrine glands. In the central nervous system (brain and spinal cord), capillary endothelia lack pores and there is little transcytotic activity.

Agents capable of diffusing through phospholipid membranes, with the epithelial thickness determining the extent and speed of absorption. In addition, cutaneous absorption is impeded by the keratin layer, the stratum corneum, which is very unevenly developed in various areas of the skin. Lüllmann, Color Atlas of Pharmacology © 2000 Thieme All rights reserved. Usage subject to terms and conditions of license. Distribution in the Body 23 Ciliated epithelium Nonkeratinized squamous epithelium Epithelium with brush border Keratinized squamous epithelium A.

And the clearance, according to the equation: D Css = ––––––––– (! · Cltot) This procedure is routinely used in intensive care hospital settings, but is otherwise impracticable. , four, three, or two, offers a practical compromise. When the daily dose is given in several divided doses, the mean plasma level shows little fluctuation. In practice, it is found that a regimen of frequent regular drug ingestion is not well adhered to by patients. The degree of fluctuation in plasma level over a given dosing interval can be reduced by use of a dosage form permitting slow (sustained) release (p.

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