By Otmar D. Wiestler (Editor), Bernhard Haendler (Editor), Dominik Mumberg (Editor)
Melanoma stem cells have initially been pointed out in leukemia and later in different good tumor forms. they've got very various homes from the majority of the tumor as they divide even more slowly and feature very effective drug resistance mechanisms. present remedies may principally spare melanoma stem cells. This ebook appears at fresh advancements within the box of melanoma stem cells and the potential impression for the id of novel remedy paradigms for melanoma.
Read or Download Cancer Stem Cells: Novel Concepts and Prospects for Tumor Therapy (Ernst Schering Foundation Symposium Proceedings 06.5) PDF
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Extra resources for Cancer Stem Cells: Novel Concepts and Prospects for Tumor Therapy (Ernst Schering Foundation Symposium Proceedings 06.5)
2002). Although somatic mutations were not detected in the SFRP1 coding sequence, a loss of heterozygosity (LOH) analysis found that 38% of informative surgical specimens had LOH in the SFRP1 gene locus (Fukui et al. 2005). It was also found that SFRP was frequently downregulated in NSCLC and mesothelioma cell lines (Lee et al. 2004). Moreover, the SFRP gene promoter was hypermethylated in more than 80% of mesothelioma primary tissues (Lee et al. 2004) and in approximately 55% of primary lung tumors.
M. edu 1 Overview of Wnt Signaling . . . . . . . . . . 1 Wnt Ligands . . . . . . . . . . . . . . 2 Wnt Receptors and Antagonists . . . . . . . . . 3 Canonical Wnt Signaling: Cytosolic and Nuclear Components . 2 Stem Cells, Cancer Stem Cells, and Lung Cancer . . . . 3 Wnt Signaling in Stem Cell Maintenance and Regeneration . 4 Wnt Signaling in Lung Cancer . . . . . . . . . 1 Wnt Ligands . . . . . . . . . . . . . . 2 Wnt Antagonists . . . .
1997). Oncogene-induced senescence has recently been recognized as a barrier to early tumor development, and expression of senescence markers has been documented in a number of preneoplastic lesions (reviewed in Sharpless and DePinho 2005; Braig and Schmitt 2006). Oncogenic Ras provokes cellular senescence by Raf-MAPK-mediated accumulation of p16 INK4a and p21 CIP1 (Serrano et al. 1997; Carnero and Beach 2004). Interestingly, p21 CIP1 is a very robust target gene directly re- Myc and Ras During Skin Tumorigenesis 19 pressed by c-Myc in a number of cell types (Blanco and Trumpp unpublished; Herold et al.