By Otmar D. Wiestler (Editor), Bernhard Haendler (Editor), Dominik Mumberg (Editor)

Melanoma stem cells have initially been pointed out in leukemia and later in different good tumor forms. they've got very various homes from the majority of the tumor as they divide even more slowly and feature very effective drug resistance mechanisms. present remedies may principally spare melanoma stem cells. This ebook appears at fresh advancements within the box of melanoma stem cells and the potential impression for the id of novel remedy paradigms for melanoma.

Show description

Read or Download Cancer Stem Cells: Novel Concepts and Prospects for Tumor Therapy (Ernst Schering Foundation Symposium Proceedings 06.5) PDF

Best oncology books

Evaluating Alternative Cancer Therapies: A Guide to the Science and Politics of an Emerging Medical Field

In comparing substitute melanoma remedies, David Hess has interviewed the key opinion leaders within the replacement melanoma remedy box - clinicians, researchers, sufferer advocacy leaders, and newshounds - who clarify their philosophy of review, their healing personal tastes, and the political and monetary hurdles to getting the required study performed.

Malignant Melanoma - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References

This can be a 3-in-1 reference publication. It supplies a whole clinical dictionary masking hundreds of thousands of phrases and expressions in terms of malignant cancer. It additionally offers large lists of bibliographic citations. eventually, it offers info to clients on how you can replace their wisdom utilizing a variety of net assets.

Palliative Care in Oncology

Palliative care offers complete aid for significantly affected sufferers with any life-limiting or life-threatening prognosis. to do that successfully, it calls for a disease-specific strategy because the sufferers’ wishes and medical context will differ looking on the underlying prognosis. specialists within the box of palliative care and oncology describe intimately the wishes of sufferers with complicated melanoma compared to people with non-cancer disorder and likewise establish the necessities of sufferers with diversified melanoma entities.

100 questions and answers about bipolar (manic-depressive) disorder

Provides doctor's and patient's perspectives of bipolar sickness. summary: the single quantity to supply the doctor's and patient's view and offers you authoritative, sensible solutions on your questions on treatment plans, coping ideas. learn extra. ..

Extra resources for Cancer Stem Cells: Novel Concepts and Prospects for Tumor Therapy (Ernst Schering Foundation Symposium Proceedings 06.5)

Sample text

2002). Although somatic mutations were not detected in the SFRP1 coding sequence, a loss of heterozygosity (LOH) analysis found that 38% of informative surgical specimens had LOH in the SFRP1 gene locus (Fukui et al. 2005). It was also found that SFRP was frequently downregulated in NSCLC and mesothelioma cell lines (Lee et al. 2004). Moreover, the SFRP gene promoter was hypermethylated in more than 80% of mesothelioma primary tissues (Lee et al. 2004) and in approximately 55% of primary lung tumors.

M. edu 1 Overview of Wnt Signaling . . . . . . . . . . 1 Wnt Ligands . . . . . . . . . . . . . . 2 Wnt Receptors and Antagonists . . . . . . . . . 3 Canonical Wnt Signaling: Cytosolic and Nuclear Components . 2 Stem Cells, Cancer Stem Cells, and Lung Cancer . . . . 3 Wnt Signaling in Stem Cell Maintenance and Regeneration . 4 Wnt Signaling in Lung Cancer . . . . . . . . . 1 Wnt Ligands . . . . . . . . . . . . . . 2 Wnt Antagonists . . . .

1997). Oncogene-induced senescence has recently been recognized as a barrier to early tumor development, and expression of senescence markers has been documented in a number of preneoplastic lesions (reviewed in Sharpless and DePinho 2005; Braig and Schmitt 2006). Oncogenic Ras provokes cellular senescence by Raf-MAPK-mediated accumulation of p16 INK4a and p21 CIP1 (Serrano et al. 1997; Carnero and Beach 2004). Interestingly, p21 CIP1 is a very robust target gene directly re- Myc and Ras During Skin Tumorigenesis 19 pressed by c-Myc in a number of cell types (Blanco and Trumpp unpublished; Herold et al.

Download PDF sample

Rated 4.18 of 5 – based on 21 votes