By Igor Jurisica, Dennis A. Wigle, Bill Wong
Melanoma Informatics in Post-Genomic period offers either the mandatory method and sensible info instruments for interpreting information within the box of scientific details technology. This, in fact, calls for analytic instruments. these instruments are garnered via constructing and assessing tools and platforms for the purchase, processing, and interpretation of sufferer information, aided by means of clinical discovery. Key demanding situations during this box contain integrating examine and medical care, sharing facts, and setting up partnerships inside and throughout sectors of sufferer prognosis and remedy.
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Additional resources for Cancer Informatics in the Post Genomic Era (Cancer Treatment and Research)
1996; Rashidi, Yang et al. 2000). The first orthotopic model of human lung cancer was developed by McLemore et al. (McLemore 1987) who implanted human lung cancer cell lines and enzymatically dissociated human lung tumors in the right lung of nude mice via an endobronchial injection. The tumors had increased growth and invasiveness within the lung as compared to the same tumors inoculated subcutaneously. However, most of the tumors remained within the right lung, with only 3% showing distant spread to lymph nodes, liver or spleen (McLemore 1987).
Subcutaneous implantation is the predominant site to transplant human tumor material into the nude mouse, since the procedure is simple and the site is readily accessible (Figure 7). This also allows for straightforward monitoring of tumor growth. Although subcutaneous xenograft models can predict clinical efficacy (Steel, Courtenay et al. 1983; Mattern, Bak et al. 1988; Boven 1992), these models have significant limitations, which include: (1) A low tumor take rate for fresh clinical specimens, with the percentage varying widely depending on the type of cancer (Mattern, Bak et al.
National Cancer Institute (NCI) started to shift from a compound-oriented screen toward disease-oriented screens. NCI employs xenografts as an integral part of its drug discovery screening strategy (Khleif SN 1997). Drugs toxic to human cancer cell lines in vitro are tested on xenografts as a secondary screen. The in vitro studies permit high throughput screening and the cell lines found sensitive to a particular drug are used to choose appropriate xenografts for further testing. Lung tumor transplants often reflect the chemosensitivities of their tumors of origin.