By Patricia A. Thomas (auth.), Patricia A. Thomas (eds.)
Rather than an exhaustive overview of the entire pathologic stipulations of the feminine breast, Breast melanoma and its Precursor Lesions makes a speciality of the present wisdom, realizing and concerns relating to breast melanoma and its benign lesions which are linked to an elevated threat for the following improvement of melanoma. This booklet objectives the language, diagnostic phrases and demanding verbal exchange that needs to happen among basic care physicians, breast surgeons, oncologists, and common surgical pathologists drawn to the pathologist’s viewpoint on those very important ailments. the quantity additionally stories the present terminology and the way to learn or write significant pathology reviews on those entities, the foils and nuances of the pathology and implications for administration, and recent matters in genomics and proteomics of those stipulations. The textual content is succinct, absolutely informative, and written in “plain language”. All chapters are provided in a uniform style, and supplemented via top of the range illustrations and tables. Breast melanoma and its Precursor Lesions can be of significant price to pathologists in addition to basic care physicians, breast surgeons, and oncologists for figuring out breast pathology and its implications for management.
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Additional info for Breast Cancer and its Precursor Lesions: Making Sense and Making It Early
Legend has it that Pia de’ Tolomei’s ghost walks the bridge on nights when the moon is full dressed in white without touching her feet to the ground. It can be difficult for the pathologist to decide where to draw the line between florid usual ductal hyperplasia without atypia, ductal hyperplasia with atypia and low grade ductal carcinoma in situ, especially on a core needle biopsy [7, 9]. To complicate matters these conditions can co-exist within the same biopsy and even the same terminal ductal lobular unit .
Pleomorphic LCIS is a recently described variant with cells similar to type B LCIS but are characterized by more pleomorphism, larger nuclei, and distinct nucleoli . Central necrosis with calcification can occur. e. a mass or calcification. e. excision with free margins with or without radiation therapy . The presence of intracytoplasmic mucin vacuoles has been described in LCIS and may result in signet ring cells, so called because these cells resemble a finger ring bearing an engraved signet.
Elsheikh TM, Silverman JF (2005) Follow-up surgical excision is indicated when breast core needle biopsies show atypical lobular hyperplasia or lobular carcinoma in situ: a correlative study of 33 patients with review of the literature. Am J Surg Pathol 29:534–543 32. Foster MC, Helvie MA, Gregory NE, Rebner M, Nees AV, Paramagul C (2004) Lobular carcinoma in situ or atypical lobular hyperplasia at core-needle biopsy: is excisional biopsy necessary? Radiology 231:813–819 33. Middleton LP, Shakeitha G, Stephens T, Stelling CB, Sneige N, Sahin AA (2003) Lobular carcinoma in situ diagnosed by core needle biopsy: when should it be excised?