By Tahira Farooqui, Akhlaq A. Farooqui

Biogenic amines are evidently taking place amines which are derived via enzymic decarboxylation of the ordinary amino acids. They belong to a category of neurotransmitters together with catecholamines (dopamine, norepinephrine, and epinephrine), indolamine (serotonin), and imidazoleamine (histamine). Biogenic amines have nice pharmacological and physiological value. the most goal of this ebook is to provide readers with finished info on pharmacology, neurochemistry and molecular neurobiology of biogenic amine within the CNS of vertebrate and invertebrates in one quantity textual content. The ebook has been organised into chapters and sections to supply a greater circulation of knowledge. additionally, this targeted quantity presents its readers with leading edge details on biogenic amines. it may be utilized by graduate scholars, postdoctoral fellows, researchers, and scientists who paintings on the pharmaceutical as a instruction manual, which describes all features of biogenic amine metabolism.

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Altered post-translational modification of AAAD after MPTP and/or altered receptor/second messenger signaling cascades secondary to the dopaminergic lesion might underlie this phenomenon (Figure 2). Indeed, the magnitude of exogenous PKA-induced AAAD phosphorylation is greater in homogenates prepared from striatum and midbrain of MPTP-lesioned mice, with the response increasing with time following the lesion (Figure 2A), and icv administration of forskolin in MPTP-mice amplifies the activation of the enzyme (Figure 2B), and causes an earlier induction of AAAD mRNA [57,59].

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6] Sourkes TL. DOPA Decarboxylase (aromatic amino acid decarboxylase). In: Horn AS, Korf J, Westerink BHC, editors. The Neurobiology of Dopamine. London: Academic Press;1979:123-132. [7] Berry MD. Mammalian central nervous system trace amines. Pharmacologic amphetamines, physiologic neuromodulators. Journal of Neurochemistry. 2004;90:257271. [8] Jaeger CB, Teitelman G, Joh TH, Albert VR, Park DH, Reis DJ. Some neurons of the rat central nervous system contain aromatic-L-amino-acid decarboxylase but not monoamines.

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