By C.K. Chu
• updated assessment at the chemistry and biology of nucleosides • sleek man made method • complete assurance of antiviral nucleosidesThis ebook summarizes the hot advances in nucleosides chemistry and chemotherapy during the last 10-15 years. It covers lately came upon nucleoside antiviral brokers, their healing facets and biochemistry, and likewise vast stories on their chiral synthesis.
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Additional resources for Antiviral Nucleosides: Chiral Synthesis and Chemotherapy
Tetrahedron 1998, 54, 9229-9272. -F. The latest progress in the synthesis of carbocyclic nucleosides. Nucleosides Nucleotides 2000,19, 651-690. ; Song, G. ; Chu, C. K. L-Nucleosides as chemotherapeutic agents. 2001, 202, 9-15. Cj) Cooperwood, J. ; Boudinot, F. ; Chu, C. K. Nucleoside and nucleotide prodrugs. In Recent Advances in Nucleosides: Chemistry and Chemotherapy. C. K. Chu Ed. 3. 2002, 91-147. ; Imbach, J. -L. Nucleoside analogs as chemotherapeutic agents: a review. Nucleosides Nucleotides 1992, 11, 903-945.
The P-L-dioxolane nucleosides show potent anti-VZV and anti-EBV activities, which can be related to the size of the halogen atoms [chlorovinyl (123) < bromovinyl (124) < iodovinyl (125) against VZV and iodovinyl < bromovinyl < chlorovinyl against EBV]. p-L-(£)-5-(2-Iodovinyl)uracil dioxolane (125, L IV-OddU) is 60-fold more potent against VZV than ACV. No inhibition of CEM cell growth or mt-DNA synthesis is observed for any compounds at concentrations up to 200 jiiM. ^^^ Unlike other D-configuration BVU analogs, such as BVdU and BVaraU, L-BV-OddU is metabolized only to its corresponding monophosphate instead of the dior triphosphate, which suggests a unique inhibitory mechanism other than DNA chain termination.
K. Structure-activity relationships of (F)-5-(2-bromovinyl)uracil nucleosides and related analogs as anti-herpesvirus agents. /. Med. Chem. 2000, 43, 2538-2546. 21. Bryant, M. ; Bridges, E. ; Faraj. ; Loi, A. ; Imbach, J. ; Schinazi, R. ; Sonmiadossi, J. -P. Antiviral L-nucleosides specific for hepatitis B virus infection. Antimicrob.