By George Klein, Sidney Weinhouse, Alexander Haddow (Eds.)

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More direct evidence that the cytotoxic test with immune serum may be detecting SV40 TSTA was provided by Smith et a2. (1970). They isolated a solubilized SV40 TSTA which could immunize animals and which could also absorb the cytotoxic activity of immune serum. Recently, Klietmann and Seemayer (1971), using the mixed hemadsorption test, showed marked differences in the concentration of specific surface antigen(s) on hamster cells transformed by normal SV40 and those transformed by UV-irradiated SV40.

This would enable one to prove that recombination of transforming genomes had occurred if the two genetic markers appeared linked in the rescued virus. “Partial” induction of SV40-transformed cells has been achieved by heat shock (45°C. , 1970b). , 1970a). The mechanism of this heat induction phenomenon is not clear, but a plausible explanation is that only a portion of the transforming viral genome has been derepressed and possibly only one of the viral coat protein polypeptides synthesized. It is not yet known whether the heat induction procedure results in the detachment of an integrated viral genome (see Section V,B) prior to capsid antigen synthesis.

In this section, we will attempt to analyze the nature of these antigens arid their relationship to each other and consider whether the changes are extrinsic (coded for by the virus) or intrinsic (due to derepression of the host cell genome). A. , 1963; Koch and Sabin, 1963). , 1964a; Pope and Rowe, 20 J. S. BUTEL, S. S. TEVETHIA, AXD J . L. MELNICK 1964). A typical pattern of nuclear fluorescence by SV40 T-antigen is shown in Fig. 1. , 1965). Kinctic studies showed that T-antigen appears 12-24 hours after infection with SV40, prior to the appearance of viral capsid antigen and progeny virions.

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