By Edward Chow, Joav Merrick

An envisioned 166,400 new circumstances of melanoma will ensue in Canada in 2008. Bone metastases regrettably stay a typical website of recurrence, with breast and prostate melanoma sufferers representing a considerable percentage of this inhabitants. Metastatic bone sickness is linked to major morbidity and mortality. ache is skilled via as much as thirds of sufferers. The analysis for sufferers with bone metastases is extremely prompted by means of tumour variety, functionality prestige, and the presence of extraosseous illness. The median survival has been considerably longer in breast melanoma sufferers with a primary relapse within the axial skeleton (24 months) as opposed to sufferers with preliminary relapse within the liver (3 months) (2). Survival after prognosis of bone metastases is prompted by means of the next improvement of extraosseous metastatic websites: 1.6 years as opposed to 2.1 years in sufferers with bone-only sickness.

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Extra resources for Advanced Cancer. Pain and Quality of Life (Health and Human Development)

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Mercadante S. Malignant bone pain: pathophysiology and treatment. Pain 1997;69(12):1-18. Janjan N. Bone metastases: approaches to management. Semin Oncol 2001;28(4 Suppl 11):28-34. Serafini AN. Therapy of metastatic bone pain. J Nucl Med 2001;42:895-906. Gralow J, Tripathy D. Managing metastatic bone pain: The role of bisphosphonates. J Pain Symp Manag 2007;33(4)462-72. 6 [8] [9] [10] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [21] [22] [23] Edward Chow, MBBS and Joav Merrick, MD, MMEdSc, DMSc Hansen BH, Keller J, Laitinen M, et al.

Therapy of metastatic bone pain. J Nucl Med 2001;42:895-906. Gralow J, Tripathy D. Managing metastatic bone pain: The role of bisphosphonates. J Pain Symp Manag 2007;33(4)462-72. 6 [8] [9] [10] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [21] [22] [23] Edward Chow, MBBS and Joav Merrick, MD, MMEdSc, DMSc Hansen BH, Keller J, Laitinen M, et al. Scandinavian Sarcoma Group Skeletal Metastasis Register. Survival after surgery for bone metastases in the pelvis and extremities. Acta Orthop Scand 2004;75:11-5.

Coleman RE. Clinical features of metastatic bone disease and risk of skeletal morbidity. Clin Cancer Res 2006;12(20 Suppl):6243-49. Coleman RE. Skeletal complications of malignancy. Cancer 1997;80(8 Suppl):1588-94. Mercadante S. Malignant bone pain: pathophysiology and treatment. Pain 1997;69(12):1-18. Janjan N. Bone metastases: approaches to management. Semin Oncol 2001;28(4 Suppl 11):28-34. Serafini AN. Therapy of metastatic bone pain. J Nucl Med 2001;42:895-906. Gralow J, Tripathy D. Managing metastatic bone pain: The role of bisphosphonates.

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